Intron a, Introna(interferon alfa-2b)
Intron A, IntronA, Viraferon (interferon alfa-2b) is a protein pharmaceutical. Interferon alfa-2b was first approved as Intron a on . It is used to treat BCR-ABL positive chronic myelogenous leukemia, brain neoplasms, chronic hepatitis b, chronic hepatitis c, and colorectal neoplasms amongst others in the USA. It has been approved in Europe to treat BCR-ABL positive chronic myelogenous leukemia, carcinoid tumor, chronic hepatitis b, chronic hepatitis c, and follicular lymphoma amongst others.
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Drug Products
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Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Interferon alfa-2b
Tradename | Proper name | Company | Number | Date | Products |
|---|---|---|---|---|---|
| Intron A | interferon alfa-2b | Merck & Co | N-103132 DISCN | 14 products |
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Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
interferon alfa-2b, Intron A, Merck Sharp & Dohme LLC | |||
| 2095-11-21 | Orphan excl. | ||
Patent Expiration
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HCPCS
Code | Description |
|---|---|
| S0148 | Injection, pegylated interferon alfa-2b, 10 mcg |
Clinical
Clinical Trials
444 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatitis c | D006526 | — | B19.2 | 4 | 12 | 31 | 14 | 20 | 77 |
| Hepatitis | D006505 | — | K75.9 | 3 | 11 | 32 | 14 | 18 | 74 |
| Hepatitis a | D006506 | EFO_0007305 | B15 | 3 | 10 | 28 | 12 | 17 | 66 |
| Chronic hepatitis c | D019698 | EFO_0004220 | B18.2 | 3 | 9 | 26 | 12 | 19 | 65 |
| Chronic hepatitis | D006521 | — | K73.9 | 3 | 3 | 7 | 2 | 1 | 15 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 2 | 6 | 4 | 1 | — | 13 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 2 | 6 | 1 | — | 8 |
| Fibrosis | D005355 | — | — | — | 2 | 4 | 1 | — | 6 |
| Hepatitis b | D006509 | — | — | — | — | 5 | 1 | — | 6 |
| Chronic hepatitis b | D019694 | EFO_0004239 | B18.1 | — | — | 4 | 1 | 1 | 6 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Melanoma | D008545 | — | — | 8 | 5 | 3 | — | 4 | 18 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 1 | 5 | 1 | — | — | 6 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | 2 | 2 | 1 | — | — | 5 |
| Coinfection | D060085 | — | — | — | 1 | 1 | — | — | 2 |
| Carcinoma | D002277 | — | C80.0 | 1 | 1 | 1 | — | — | 2 |
| Recurrence | D012008 | — | — | — | 1 | 1 | — | — | 2 |
| Menopause | D008593 | EFO_0003922 | N95 | — | — | 1 | — | — | 1 |
| Neoadjuvant therapy | D020360 | — | — | — | — | 1 | — | — | 1 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | — | — | 1 | — | — | 1 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 1 | 3 | — | — | — | 4 |
| Neoplasms | D009369 | — | C80 | 2 | 1 | — | — | — | 3 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 3 | 2 | — | — | — | 3 |
| Myeloid leukemia | D007951 | — | C92 | — | 3 | — | — | — | 3 |
| Communicable diseases | D003141 | — | — | — | 2 | — | — | — | 2 |
| Hiv | D006678 | — | O98.7 | 1 | 1 | — | — | — | 2 |
| Cutaneous malignant melanoma | D000096142 | — | — | — | 1 | — | — | 1 | 2 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | — | 1 | — | — | — | 1 |
| Gastrointestinal stromal tumors | D046152 | EFO_0000505 | C49.A | — | 1 | — | — | — | 1 |
| Cholangiocarcinoma | D018281 | — | C22.1 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Kidney neoplasms | D007680 | EFO_0003865 | C64 | 1 | — | — | — | — | 1 |
| Aids-related opportunistic infections | D017088 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Substance-related disorders | D019966 | EFO_0003890 | F13 | — | — | — | — | 1 | 1 |
| Intravenous substance abuse | D015819 | — | — | — | — | — | — | 1 | 1 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | — | — | — | — | 1 | 1 |
| Lymphoma | D008223 | — | C85.9 | — | — | — | — | 1 | 1 |
| Follicular lymphoma | D008224 | — | C82 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Interferon alfa-2b |
| INN | — |
| Description | Interferon alfa-2b is an antiviral or antineoplastic drug. It is a recombinant form of the protein Interferon alpha-2 that was originally sequenced and produced recombinantly in E. coli in the laboratory of Charles Weissmann at the University of Zurich, in 1980. It was developed at Biogen, and ultimately marketed by Schering-Plough under the trade name Intron-A. It was also produced in 1986 in recombinant human form, in the Center for Genetic Engineering and Biotechnology of Havana, Cuba, under the name Heberon® Alfa R.
|
| Classification | Protein |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201558 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB00105 |
| UNII ID | — |
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16,936 adverse events reported
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